used to indicate a contrast with a previous statement (e.g., however, rather, actually, etc.)
Examples
ᐲᓕᔥ ᒫᑲ ᓃᔣᐤ ᑮ ᑲᑴᒋᒥᑯᐤ, ᒨᓚ ᒫᑲ ᔖᑰᒡ ᑮ ᐅᐦᒋ ᒦᓓᐤ᙮ At last he asked him twice, he did not, however, give her to him. Harvey Smallboy - Cree Notes & Texts collected by Truman Michelson [1935]
ᔖᑰᒡ, ᑭ ᐗᓂ ᑑᑌᓈᐙᐤ, ᓀᔥᑕ ᑭ ᒌᔑᐦᐃᐙᓈᐙᐤ, ᐆᒣᓕᐤ ᓀᔥᑕ ᑭ ᑑᑕᐙᐙᐗᒃ ᑮᒋᔖᓂᐙᐗᒃ᙮ Nay, ye do wrong, and defraud, and that your brethren. 1 Corinthians 6:8 [1876]
2
used to emphasize the factuality of a statement (e.g., certainly, surely, undoubtedly, etc.)
Examples
ᔖᑰᒡ ᒨᓚ ᓂ ᑭᔅᑫᓕᐦᑌᓈᓐ ᑖᓂ ᐁᔅᐱᔑᓈᑯᓯᔭᓐ, ᓂᑮ ᐃᑖᓈᓐ᙮ "We certainly don't know how far you are," we told him. Herbert McLeod - The Deborah James Corpus [1980]